Pan-Cancer analysis of whole genomes
Published in Nature, 2020
Recommended citation: The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium (includes Bruzos AL). (2020). "Pan-Cancer analysis of whole genomes." Nature. 578:82-93. doi: 10.1038/s41586-020-1969-6 - IF(2020) = 49.962 https://doi.org/10.1038/s41586-020-1969-6
Alicia’s Citation:
The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium (includes Bruzos A.L.). 2020. “Pan-Cancer analysis of whole genomes”. Nature, 578:82-93. IF = 49.962 (2020).
About the paper:
Scope: The flagship of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium that describes the main scientific findings from the analyses of 2,954 cancer whole genomes and their matched normal tissues across 38 tumour types. The study provides insights into the landscape of genetic alterations driving cancer, including both coding and non-coding elements. Key findings include the prevalence of driver mutations in cancer genomes, the occurrence of chromothripsis as an early event in tumor evolution, and the role of abnormal telomere maintenance mechanisms. Additionally, the study explores the influence of germline variants on somatic mutation patterns and identifies new mutational signatures and mechanisms driving cancer development. Impact: It represents an effort to understand the genomic landscape of cancer and has far-reaching implications for diagnosis, treatment, and management. By analysing a large cohort of whole cancer genomes, the study uncovers fundamental insights into the genetic mechanisms of cancer evolution. My contribution: I did bioinformatic analysis and data visualization of figure 6d of this paper. Personal importance: This was my first peer-reviewed publication so, it’s an honour that it was published in a high-impact journal and featured on the cover of the issue.
More information:
Visit online version: doi.org/10.1038/s41586-020-1969-6
Download PDF paper here
Authorship:
Position of AL Bruzos: 60
Total number of authors: 1340
Journal information
ISSN: 0028-0836
eISSN: 1476-4687
Current Publisher: NATURE PORTFOLIO. HEIDELBERGER PLATZ 3, BERLIN 14197, GERMANY
Journal Impact Factor (JIF): 49.962 (2020)
WoS Research Areas: Science & Technology - Other Topics
JCR Category: MULTIDISCIPLINARY SCIENCES in SCIE edition
JCR Category Rank: 1/73
JCR Category Quartile: Q1
Peer-review process:
Received: 29 July 2018
Accepted: 11 December 2019
Published: 05 February 2020
Journal cover:
