Rodriguez-Martin, B. et al. (includes Bruzos A.L.). 2020. “Pan-Cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition”. Nature Genetics, 52:306-319. IF = 25.455.
About the paper:
Here we identify a new mutational mechanism in cancer by with aberrant integration of L1 elements promote chromosomal rearrangements such as Megabase-size genomic deletions that on occasion remove tumour suppressor genes, contributing to cancer progression. I catalogued the retrotransposition events of LINE-1.
Received: 21 September 2017
Accepted: 26 November 2019
Published: 05 February 2020