Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture

Published in Nature Communications, 2021

Recommended citation: Álvarez, E. G. et al. (2021). "Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture." Nature Communications. 12:6910. https://doi.org/10.1038/s41467-021-26805-8

Alicia’s Citation:
Álvarez, E. G. et al. (includes Bruzos A.L.). 2021. “Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture.” Nature Communications, 12:6910. IF(2020) = 14.92.

About the paper:
Here, we identify and characterize a remarkable mutational mechanism in human hepatocellular carcinoma caused by Hepatitis B virus, by which DNA molecules from the virus are inserted into the tumour genome causing dramatic changes in its configuration, including non-homologous chromosomal fusions and megabase-size telomeric deletions. I participated in the wet-lab validation of the mechanism.

More information:
Visit online version: doi.org/10.1038/s41467-021-26805-8
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Peer-review process:
Received: 08 April 2021
Accepted: 22 October 2021
Published: 25 November 2021