Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture

Alicia’s citation:
Álvarez, E. G. et al. (includes Bruzos A.L.). 2021. “Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture.” Nature Communications, 12:6910. IF(2021) = 17.694.

All authors citation:
Álvarez, EG; Demeulemeester, J; Otero, P; Jolly, C; García-Souto, D; Pequeño-Valtierra, A; Zamora, J; Tojo, M; Temes, J; Baez-Ortega, A; Rodriguez-Martin, B; Oitaben, A; Bruzos, AL; … Tubio, JMC. 2021. Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture. Nature Communications, 12:6910. IF(2021) = 17.694. DOI: https://doi.org/10.1038/s41467-021-26805-8

About the paper:
Here, we identify and characterize a remarkable mutational mechanism in human hepatocellular carcinoma caused by Hepatitis B virus, by which DNA molecules from the virus are inserted into the tumour genome causing dramatic changes in its configuration, including non-homologous chromosomal fusions and megabase-size telomeric deletions. I participated in the wet-lab validation of the mechanism.

More information:
Visit online version: doi.org/10.1038/s41467-021-26805-8
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Authorship:
Position of AL Bruzos: 13
Total number of authors: 43

Journal information
eISSN: 2041-1723
Current Publisher: NATURE PORTFOLIO. HEIDELBERGER PLATZ 3, BERLIN 14197, GERMANY
Journal Impact Factor (JIF): 17.694 (2021)
WoS Research Areas: Science & Technology - Other Topics
JCR Category: MULTIDISCIPLINARY SCIENCES in SCIE edition
JCR Category Rank: 6/73
JCR Category Quartile: Q1

Peer-review process:
Received: 08 April 2021
Accepted: 22 October 2021
Published: 25 November 2021