Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture
Published in Nature Communications, 2021
Recommended citation: Álvarez, EG et al (includes Bruzos AL). (2021). "Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture." Nature Communications. 12:6910. doi: 10.1038/s41467-021-26805-8 - IF(2021) = 17.694 https://doi.org/10.1038/s41467-021-26805-8
Alicia’s citation:
Álvarez, E. G. et al. (includes Bruzos A.L.). 2021. “Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture.” Nature Communications, 12:6910. IF(2021) = 17.694.
All authors citation:
Álvarez, EG; Demeulemeester, J; Otero, P; Jolly, C; García-Souto, D; Pequeño-Valtierra, A; Zamora, J; Tojo, M; Temes, J; Baez-Ortega, A; Rodriguez-Martin, B; Oitaben, A; Bruzos, AL; … Tubio, JMC. 2021. Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture. Nature Communications, 12:6910. IF(2021) = 17.694. DOI: https://doi.org/10.1038/s41467-021-26805-8
About the paper:
Scope: we identified and characterized a mutational mechanism in human hepatocellular carcinoma (HCC) caused by Hepatitis B virus (HBV), by which DNA molecules from the virus are inserted into the tumour genome causing genomic rearrangements, including non-homologous chromosomal fusions, dicentric chromosomes, and large telomeric deletions. It was present in at least 8% of HCC tumours, and provided the necessary driver rearrangements for cancer progression, including the loss of crucial tumor suppressor genes. They occur early during liver cancer evolution, with some rearrangements estimated to occur up to two decades before cancer diagnosis. Impact: The research underscores the importance of understanding the genomic impact of HBV integration in liver cancer and highlights the clinical implications of early detection of HBV-mediated rearrangements. My contribution: I participated in the wet-lab validation of the mechanism.
More information:
Visit online version: doi.org/10.1038/s41467-021-26805-8
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Authorship:
Position of AL Bruzos: 13
Total number of authors: 43
Journal information
eISSN: 2041-1723
Current Publisher: NATURE PORTFOLIO. HEIDELBERGER PLATZ 3, BERLIN 14197, GERMANY
Journal Impact Factor (JIF): 17.694 (2021)
WoS Research Areas: Science & Technology - Other Topics
JCR Category: MULTIDISCIPLINARY SCIENCES in SCIE edition
JCR Category Rank: 6/73
JCR Category Quartile: Q1
Peer-review process:
Received: 08 April 2021
Accepted: 22 October 2021
Published: 25 November 2021